2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101202A
    (Rac)-SNC80 1217643-87-2 98%
    (Rac)-SNC80 is a racemate of SNC80 (HY-101202). SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment.
    (Rac)-SNC80
  • HY-10121S2
    Asenapine-13C,d3 2747915-30-4 98%
    Asenapine-13C,d3 is 13C and deuterated labeled Asenapine (HY-10121). Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder.
    Asenapine-13C,d3
  • HY-101238S
    Agmatine-d8 sulfate 909556-32-7 98%
    Agmatine-d8 sulfate is a deuterium labeled Agmatine sulfate (HY-101238). Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.
    Agmatine-d8 sulfate
  • HY-101240R
    Propranolol glycol (Standard) 36112-95-5
    Propranolol glycol (Standard) is the analytical standard of Propranolol glycol. This product is intended for research and analytical applications. Propranolol glycol is a metabolite of propranolol (HY-B0573B). Propranolol glycol shows instantaneous anticonvulsant activity.
    Propranolol glycol (Standard)
  • HY-101299A
    Dihydrexidine 123039-93-0 98%
    Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity. Dihydrexidine can stimulate YAP phosphorylation.
    Dihydrexidine
  • HY-101322A
    MM 77 dihydrochloride 159187-70-9 98%
    MM 77 dihydrochloride is a potent postsynaptic antagonist of the 5-HT1A receptor. MM 77 dihydrochloride exhibits anxiolytic-like activity.
    MM 77 dihydrochloride
  • HY-101349A
    L 741742 hydrochloride 874882-93-6 98%
    L 741742 hydrochloride is an orally active and selective antagonist of hD4 receptors. L 741742 hydrochloride has a good brain penetration. L 741742 hydrochloride can be used in study nervous system disorders, particularly schizophrenia.
    L 741742 hydrochloride
  • HY-101377A
    R(+)-8-OH-DPAT hydrobromide 78095-19-9 98%
    R(+)-8-OH-DPAT ((R)-8-Hydroxy-2-dipropylaminotetralin) hydrobromide is a potent 5-HT1A agonist. R(+)-8-OH-DPAT potentiates SUL (HY-B1059)-induced dopamine (DA) release in the medial prefrontal cortex (mPFC).
    R(+)-8-OH-DPAT hydrobromide
  • HY-101377B
    S(-)-8-OH-DPAT hydrobromide 78095-20-2 98%
    S(-)-8-OH-DPAT (S(-)-8-Hydroxy-2-dipropylaminotetralin) hydrobromide is an enantiomer of 8-OH-DPAT hydrobromide. 8-OH-DPAT hydrobromide is a potent, selective 5-HT1A agonist with a pIC50 of 8.19.
    S(-)-8-OH-DPAT hydrobromide
  • HY-101380A
    BU226 hydrochloride 1186195-56-1 98.93%
    BU226 hydrochloride is a selective imidazoline 2 (I2) receptors ligand with an Ki of 1.4 nM for I2 and an IC50 of 534.5 nM for I1. BU226 hydrochloride can be used for researching antidepressant.
    BU226 hydrochloride
  • HY-101392R
    Harmane (Standard) 486-84-0
    Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect.
    Harmane (Standard)
  • HY-101414A
    L-DABA hydrobromide 73143-97-2 ≥98.0%
    L-DABA (L-2,4-Diaminobutyric acid) hydrobromide is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.
    L-DABA hydrobromide
  • HY-101416R
    Vanilpyruvic acid (Standard) 1081-71-6
    Vanilpyruvic acid (Standard) is the analytical standard of Vanilpyruvic acid. This product is intended for research and analytical applications. Vanilpyruvic acid is a catecholamine metabolite and precursor to vanillactic acid.
    Vanilpyruvic acid (Standard)
  • HY-101437A
    Ralfinamide mesylate 202825-45-4 98%
    Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain.
    Ralfinamide mesylate
  • HY-101440A
    Indantadol hydrochloride 202914-18-9 98%
    Indantadol (CHF-3381) hydrochloride is a novel putative NMDA antagonist. Indantadol blocks the NMDA receptor in a dose-dependent and prevents cell damage.
    Indantadol hydrochloride
  • HY-101478A
    Fenobam hydrate 63540-28-3 98%
    Fenobam hydrate is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam hydrate shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam hydrate has anxiolytic activity, inhibits self-administration behavior in rat, and induces apoptosis in cancer cells. Fenobam hydrate can be used for research on neurological diseases, cancer and drug addiction.
    Fenobam hydrate
  • HY-101480A
    Xylamidine tosylate 6443-40-9 98%
    Xylamidine tosylate is a serotonin inhibitor with reproductive activity. Xylamidine tosylate can affect reproductive processes and may be used as an experimental tool in related research. The mechanism of action of Xylamidine tosylate involves the regulation of the serotonin system.
    Xylamidine tosylate
  • HY-101541R
    Docosahexaenoic acid methyl ester (Standard) 2566-90-7
    Docosahexaenoic acid methyl ester (Standard) is the analytical standard of Docosahexaenoic acid methyl ester. This product is intended for research and analytical applications. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.
    Docosahexaenoic acid methyl ester (Standard)
  • HY-101558B
    Elzasonan hydrochloride 220322-05-4 98%
    Elzasonan hydrochloride is a 5-hydroxytryptamine 1B and 5-hydroxytryptamine 1D receptor antagonist. Elzasonan hydrochloride can be used in depression research.
    Elzasonan hydrochloride
  • HY-101619A
    Abaperidone hydrochloride 183849-45-8 98%
    Abaperidone hydrochloride is a potent antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM.
    Abaperidone hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity